Uricolysis in Normal and Gouty Individuals

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Uricolysis in normal and gouty individuals.

One of the many theories of gout has been that the hyperuricaemia in gout is due to a defect in uricolysis. Uricase has never been demonstrated in human tissue; thus this argument is on tenuous ground. In the determination of the uric acid pool and turnover rate, Benedict and others (1949) consistently observed a discrepancy between turnover rate and excretion which they designated the uric aci...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1955

ISSN: 0003-4967

DOI: 10.1136/ard.14.4.409